Mouse Ubash3b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ubash3b
Locus ID	72828
Kit Components	GA209350G1, Ubash3b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209350G2, Ubash3b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209350G3, Ubash3b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_176860, NM_001357412
Synonyms	2810457I06Rik; BB125008; p70; TULA-2
Summary	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.[UniProtKB/Swiss-Prot Function]

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