Mouse Hpf1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hpf1
Locus ID	72612
Kit Components	GA209290G1, Hpf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209290G2, Hpf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209290G3, Hpf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028299, NM_001357270, NM_001357271, NR_151662
Synonyms	2700029M09Rik; C4orf27; C230006B22Rik
Summary	Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1.[UniProtKB/Swiss-Prot Function]

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