Mouse Lypd1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lypd1
Locus ID	72585
Kit Components	GA209284G1, Lypd1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209284G2, Lypd1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209284G3, Lypd1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001311089, NM_001311090, NM_145100
Synonyms	2700050C12Rik; AI853408; C530008O16Rik; Lynx2; Lypdc1
Summary	Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs (PubMed:19246390). May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:26276394, PubMed:25716842). May be involved in the control of anxiety (PubMed:19246390).[UniProtKB/Swiss-Prot Function]

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