Mouse Zup1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zup1
Locus ID	72580
Kit Components	GA209282G1, Zup1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209282G2, Zup1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209282G3, Zup1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028287, NM_001359455, NM_001359456, NR_153113
Synonyms	2700019D07Rik
Summary	Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.[UniProtKB/Swiss-Prot Function]

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