Mouse Brap activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Brap
Locus ID	72399
Kit Components	GA209228G1, Brap gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209228G2, Brap gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209228G3, Brap gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001289543, NM_001289544, NM_028227
Synonyms	3010002G07Rik; BRAP2; IMP
Summary	Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity).[UniProtKB/Swiss-Prot Function]

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