Mouse Zfyve19 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zfyve19
Locus ID	72008
Kit Components	GA209057G1, Zfyve19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209057G2, Zfyve19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209057G3, Zfyve19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164827, NM_028054
Synonyms	1500041L05Rik; ANCHR
Summary	Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity).[UniProtKB/Swiss-Prot Function]

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