Mouse Dync2i2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dync2i2
Locus ID	71820
Kit Components	GA208961G1, Dync2i2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208961G2, Dync2i2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208961G3, Dync2i2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001008498
Synonyms	3200002I06Rik
Summary	Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation (By similarity).[UniProtKB/Swiss-Prot Function]

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