Mouse Ranbp3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ranbp3
Locus ID	71810
Kit Components	GA208958G1, Ranbp3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208958G2, Ranbp3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208958G3, Ranbp3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001252466, NM_001252467, NM_027933, NR_045519
Synonyms	2610024N24Rik; AA408221
Summary	Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity).[UniProtKB/Swiss-Prot Function]

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