Mouse Marchf8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Marchf8
Locus ID	71779
Kit Components	GA208943G1, Marchf8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208943G2, Marchf8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208943G3, Marchf8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001302383, NM_001302384, NM_001302385, NM_027920
Synonyms	1300017E09Rik; MARCH-VIII; Mir
Summary	The protein encoded by this gene is a member of the membrane-associated really interesting new gene-CH family of proteins. These proteins are E3 ubiquitin-protein ligases that modulate antigen presentation by downregulating major histocompatibility complex class II surface expression through endocytosis. The transcript is primarily expressed by dendritic cells and macrophages. Overexpression of this gene in antigen presenting cells results in immune defective phenotypes, including resistance to autoimmune disease onset. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

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