Mouse Armcx3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Armcx3
Locus ID	71703
Kit Components	GA208899G1, Armcx3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208899G2, Armcx3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208899G3, Armcx3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_027870, NM_001358520, NM_001358521
Synonyms	1200004E24Rik; AI450003; ALEX3
Summary	Regulates mitochondrial aggregation and transport in axons in living neurons (PubMed:22569362, PubMed:23844091). May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2 (PubMed:22569362). Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1 (PubMed:23844091). Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters (PubMed:19304657).[UniProtKB/Swiss-Prot Function]

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