Mouse Uvssa activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Uvssa
Locus ID	71101
Kit Components	GA208729G1, Uvssa gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208729G2, Uvssa gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208729G3, Uvssa gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081101, NM_027674, NR_153107, NR_153108
Synonyms	4933407H18Rik; D330017J19Rik; Kiaa1530; mKIAA1530
Summary	Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity).[UniProtKB/Swiss-Prot Function]

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