Mouse Crtc3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Crtc3
Locus ID	70461
Kit Components	GA208532G1, Crtc3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208532G2, Crtc3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208532G3, Crtc3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_173863
Synonyms	2610312F20Rik; 6332415K15Rik; AI429792; BC011210; TORC3
Summary	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348, PubMed:30611118). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation (By similarity). Enhances the interaction of CREB1 with TAF4 (By similarity). Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR (By similarity). Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).[UniProtKB/Swiss-Prot Function]

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