Mouse Med23 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Med23
Locus ID	70208
Kit Components	GA208446G1, Med23 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208446G2, Med23 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208446G3, Med23 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001166416, NM_027347
Synonyms	130kDa; 3000002A17Rik; Crsp3; ESTM7; mKIAA1216; Sur2; X83317
Summary	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.[UniProtKB/Swiss-Prot Function]

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