Mouse Fbxo7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxo7
Locus ID	69754
Kit Components	GA208310G1, Fbxo7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208310G2, Fbxo7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208310G3, Fbxo7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310745, NM_001347151, NM_153195
Synonyms	2410015K21Rik; A230052G17Rik; AI117679; AW260462; C85118
Summary	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).[UniProtKB/Swiss-Prot Function]

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