Mouse Iqcg activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Iqcg
Locus ID	69707
Kit Components	GA208288G1, Iqcg gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208288G2, Iqcg gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208288G3, Iqcg gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_178378
Synonyms	2400003L07Rik; esgd12d; G1-374-12; repro1; stubby12d
Summary	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (By similarity). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility (PubMed:24362311, PubMed:24849454).[UniProtKB/Swiss-Prot Function]

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