Mouse Ctdspl activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ctdspl
Locus ID	69274
Kit Components	GA208112G1, Ctdspl gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208112G2, Ctdspl gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208112G3, Ctdspl gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_133710
Synonyms	2810418J22Rik; AI426263; HYA22; SCP3
Summary	Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).[UniProtKB/Swiss-Prot Function]

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