Mouse Cdk12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cdk12
Locus ID	69131
Kit Components	GA208063G1, Cdk12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208063G2, Cdk12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208063G3, Cdk12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001109626, NM_001109628, NM_026952
Synonyms	1810022J16Rik; AI646528; Crk7; Crkrs; D11Ertd752e; Pksc
Summary	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.[UniProtKB/Swiss-Prot Function]

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