Mouse Cnot8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cnot8
Locus ID	69125
Kit Components	GA208060G1, Cnot8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208060G2, Cnot8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208060G3, Cnot8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_026949, NM_001356477, NM_001363084, NM_001363085, NM_001363086
Synonyms	1500015I04Rik; 1810022F04Rik; AA536816; AU015770; AU043059
Summary	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.[UniProtKB/Swiss-Prot Function]

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