Mouse Ddi2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ddi2
Locus ID	68817
Kit Components	GA207947G1, Ddi2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207947G2, Ddi2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207947G3, Ddi2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001017966
Synonyms	1110056G13Rik; 1700027M01Rik; 9130022E05Rik; AI604911; AU040698
Summary	Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.[UniProtKB/Swiss-Prot Function]

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