Mouse Rreb1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rreb1
Locus ID	68750
Kit Components	GA207919G1, Rreb1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207919G2, Rreb1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207919G3, Rreb1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001013392, NM_001039188, NM_001177868, NM_001177869, NM_026830, NR_033218, NR_033615
Synonyms	1110037N09Rik; AA414966; B930013M22Rik
Summary	Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an elevated susceptibility to pristane-induced tumors.[UniProtKB/Swiss-Prot Function]

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