Mouse Carmil1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Carmil1
Locus ID	68732
Kit Components	GA207910G1, Carmil1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207910G2, Carmil1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207910G3, Carmil1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001311122, NM_026825, NM_177807
Synonyms	1110037D04Rik; AI425970; CARMIL; CARML1; D130057M20; Lrrc16; Lrrc16a
Summary	Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:16054028).[UniProtKB/Swiss-Prot Function]

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