Mouse Tab2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tab2
Locus ID	68652
Kit Components	GA207884G1, Tab2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207884G2, Tab2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207884G3, Tab2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_138667, NM_001359534
Synonyms	1110030N06Rik; A530078N03Rik; Map3k7ip2; mKIAA0733
Summary	Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity).[UniProtKB/Swiss-Prot Function]

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