Mouse Fbxl15 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxl15
Locus ID	68431
Kit Components	GA207810G1, Fbxl15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207810G2, Fbxl15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207810G3, Fbxl15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_133694
Synonyms	0710008C12Rik; Fbxo37
Summary	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).[UniProtKB/Swiss-Prot Function]

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