Mouse Spindoc activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Spindoc
Locus ID	68229
Kit Components	GA207735G1, Spindoc gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207735G2, Spindoc gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207735G3, Spindoc gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033139, NM_001167831
Synonyms	1700105P06Rik
Summary	Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway (PubMed:29061846). Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (By similarity).[UniProtKB/Swiss-Prot Function]

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