Mouse Pak1ip1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pak1ip1
Locus ID	68083
Kit Components	GA207672G1, Pak1ip1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207672G2, Pak1ip1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207672G3, Pak1ip1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_026550
Synonyms	5830431I15Rik; 5930415H02Rik; AA419825; AI314040; AW556169; Gdpd1; PIP1
Summary	Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.[UniProtKB/Swiss-Prot Function]

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