Mouse Tespa1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tespa1
Locus ID	67596
Kit Components	GA207412G1, Tespa1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207412G2, Tespa1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207412G3, Tespa1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_183264
Synonyms	5830405N20Rik; A430001F24Rik; AI450549
Summary	May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment (By similarity). Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes.[UniProtKB/Swiss-Prot Function]

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