Mouse Frmd8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Frmd8
Locus ID	67457
Kit Components	GA207341G1, Frmd8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207341G2, Frmd8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207341G3, Frmd8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_026169
Synonyms	1200004M23Rik; 2310035N23Rik; 4931429L16Rik; AU018809
Summary	Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333). By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity).[UniProtKB/Swiss-Prot Function]

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