Mouse Cxxc5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cxxc5
Locus ID	67393
Kit Components	GA207305G1, Cxxc5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207305G2, Cxxc5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207305G3, Cxxc5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_133687, NM_001357458, NM_001357459
Synonyms	4930415K17Rik
Summary	May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity).[UniProtKB/Swiss-Prot Function]

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