Mouse Zc3h13 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zc3h13
Locus ID	67302
Kit Components	GA207253G1, Zc3h13 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207253G2, Zc3h13 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207253G3, Zc3h13 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_026083, NM_001359875, NM_027377
Synonyms	2600010B19Rik; 3110050K21Rik; 4930570G11Rik; C87618
Summary	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3' UTR (PubMed:29547716). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (PubMed:29547716). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (PubMed:29547716). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (PubMed:29535189).[UniProtKB/Swiss-Prot Function]

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