Mouse Socs4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Socs4
Locus ID	67296
Kit Components	GA207249G1, Socs4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207249G2, Socs4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207249G3, Socs4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_080843
Synonyms	3110032M18Rik; A730004F22Rik; AI427843; AU015727; AU015859; Socs7
Summary	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).[UniProtKB/Swiss-Prot Function]

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