Mouse Eif2s2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Eif2s2
Locus ID	67204
Kit Components	GA207199G1, Eif2s2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207199G2, Eif2s2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207199G3, Eif2s2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_026030
Synonyms	38kDa; 2810026E11Rik; AA408636; AA571381; AA986487; AW822225; D2Ertd303e; EIF2; EIF2B
Summary	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).[UniProtKB/Swiss-Prot Function]

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