Mouse Gp2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gp2
Locus ID	67133
Kit Components	GA207159G1, Gp2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207159G2, Gp2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207159G3, Gp2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_025989
Synonyms	2310037I18Rik; AV060639
Summary	Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participates to the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.[UniProtKB/Swiss-Prot Function]

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