Mouse Pi4k2b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pi4k2b
Locus ID	67073
Kit Components	GA207123G1, Pi4k2b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207123G2, Pi4k2b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207123G3, Pi4k2b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_025951, NM_028744
Synonyms	2610042N09Rik; 4933409G22Rik
Summary	Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity).[UniProtKB/Swiss-Prot Function]

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