Mouse Ndc80 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ndc80
Locus ID	67052
Kit Components	GA207110G1, Ndc80 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207110G2, Ndc80 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207110G3, Ndc80 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023294
Synonyms	2610020P18Rik; AV139730; HEC; HEC1; Kntc2
Summary	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.[UniProtKB/Swiss-Prot Function]

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