Mouse Nuf2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nuf2
Locus ID	66977
Kit Components	GA207061G1, Nuf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207061G2, Nuf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207061G3, Nuf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023284, NM_001355159
Synonyms	2410003C07Rik; AU044112; C85691; Cdca1; NUF2R
Summary	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.[UniProtKB/Swiss-Prot Function]

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