Mouse Ubxn6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ubxn6
Locus ID	66530
Kit Components	GA206828G1, Ubxn6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206828G2, Ubxn6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206828G3, Ubxn6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_024432
Synonyms	1200008L11Rik; 2210415J11Rik; AU040909; Ubxd1; Ubxdc2
Summary	May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.[UniProtKB/Swiss-Prot Function]

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