Mouse Chtop activation kit by CRISPRa

CAT#: GA206821

Chtop CRISPRa kit - CRISPR gene activation of mouse chromatin target of PRMT1



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CNY 12255.00


货期*
4周

规格
    • 1 kit

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Chtop
Locus ID 66511
Kit Components

GA206821G1, Chtop gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA206821G2, Chtop gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA206821G3, Chtop gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Reference Data
RefSeq NM_001293776, NM_001293777, NM_001293778, NM_001293779, NM_001293780, NM_001293781, NM_001293782, NM_023215
Synonyms 2500003M10Rik; Fop; Srag
Summary Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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