Mouse Chtop activation kit by CRISPRa
CAT#: GA206821
Chtop CRISPRa kit - CRISPR gene activation of mouse chromatin target of PRMT1
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Chtop |
Locus ID | 66511 |
Kit Components | GA206821G1, Chtop gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206821G2, Chtop gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206821G3, Chtop gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_001293776, NM_001293777, NM_001293778, NM_001293779, NM_001293780, NM_001293781, NM_001293782, NM_023215 |
Synonyms | 2500003M10Rik; Fop; Srag |
Summary | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN503337 | Chtop - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |