Mouse Alkbh7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Alkbh7
Locus ID	66400
Kit Components	GA206754G1, Alkbh7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206754G2, Alkbh7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206754G3, Alkbh7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_025538, NM_027372
Synonyms	2310045B01Rik; 2510008E23Rik; Abh7; Spata11
Summary	May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity (By similarity). Involved in fatty acid metabolism.[UniProtKB/Swiss-Prot Function]

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