Mouse Nosip activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nosip
Locus ID	66394
Kit Components	GA206749G1, Nosip gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206749G2, Nosip gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206749G3, Nosip gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163684, NM_025533
Synonyms	2310061K06Rik; CGI-25
Summary	E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (PubMed:25546391). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).[UniProtKB/Swiss-Prot Function]

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