Mouse Sf3b5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sf3b5
Locus ID	66125
Kit Components	GA206591G1, Sf3b5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206591G2, Sf3b5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206591G3, Sf3b5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175102
Synonyms	10kDa; 1110005L13Rik; AU043053; Sf3b10
Summary	Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.[UniProtKB/Swiss-Prot Function]

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