Mouse Slc4a8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Slc4a8
Locus ID	59033
Kit Components	GA206346G1, Slc4a8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206346G2, Slc4a8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206346G3, Slc4a8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347102, NM_021530
Synonyms	AW493845; C230026C11; kNBC-3; NDCBE
Summary	Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.[UniProtKB/Swiss-Prot Function]

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