Mouse Wrap73 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wrap73
Locus ID	59002
Kit Components	GA206323G1, Wrap73 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206323G2, Wrap73 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206323G3, Wrap73 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_021499
Synonyms	2610044M17Rik; 5330425N03Rik; Dd57; Wrap73
Summary	The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (By similarity).[UniProtKB/Swiss-Prot Function]

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