Mouse Pidd1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pidd1
Locus ID	57913
Kit Components	GA206242G1, Pidd1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206242G2, Pidd1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206242G3, Pidd1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022654, NM_001360523, NM_001360524, NR_153591
Synonyms	1200011D09Rik; AU042446; Lrdd; Pidd
Summary	Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity).[UniProtKB/Swiss-Prot Function]

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