Mouse Gsdma activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gsdma
Locus ID	57911
Kit Components	GA206240G1, Gsdma gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206240G2, Gsdma gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206240G3, Gsdma gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_021347
Synonyms	BB149167; Gsdm; Gsdm1; Gsdma1; H312E
Summary	May promote pyroptosis. Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. The physiological relevance of these observations is unknown.[UniProtKB/Swiss-Prot Function]

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