Mouse Il17re activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il17re
Locus ID	57890
Kit Components	GA206236G1, Il17re gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206236G2, Il17re gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206236G3, Il17re gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001034029, NM_001034031, NM_145826, NM_001362204, NM_001362205
Synonyms	AA589509; IL-17RE; Il25r
Summary	Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors.[UniProtKB/Swiss-Prot Function]

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