Mouse Zc3h8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zc3h8
Locus ID	57432
Kit Components	GA206186G1, Zc3h8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206186G2, Zc3h8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206186G3, Zc3h8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020594
Synonyms	AU020882; E130108N08Rik; Fliz1; Zc3hdc8
Summary	Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene.[UniProtKB/Swiss-Prot Function]

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