Mouse Srd5a3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Srd5a3
Locus ID	57357
Kit Components	GA206174G1, Srd5a3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206174G2, Srd5a3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206174G3, Srd5a3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020611
Synonyms	1110025P14Rik; A430076C09; AV364670; AW987574; D730040M03Rik; H5ar; S5AR 3; Srd5a2l
Summary	Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).[UniProtKB/Swiss-Prot Function]

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