Mouse Slc12a5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Slc12a5
Locus ID	57138
Kit Components	GA206127G1, Slc12a5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206127G2, Slc12a5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206127G3, Slc12a5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020333, NM_001355480, NM_001355481
Synonyms	KCC2; mKIAA1176
Summary	Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.[UniProtKB/Swiss-Prot Function]

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