Mouse Dnajb2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dnajb2
Locus ID	56812
Kit Components	GA206104G1, Dnajb2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206104G2, Dnajb2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206104G3, Dnajb2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159883, NM_001159884, NM_001159885, NM_020266, NM_178055
Synonyms	2700059H22Rik; Dnajb10; Hsj1; mDj8
Summary	Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.[UniProtKB/Swiss-Prot Function]

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