Mouse Amotl2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Amotl2
Locus ID	56332
Kit Components	GA205913G1, Amotl2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205913G2, Amotl2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205913G3, Amotl2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_019764
Synonyms	AW549739; C79691; Lccp; MASCOT; mKIAA0989
Summary	Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity).[UniProtKB/Swiss-Prot Function]

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